RNASEL Pre-design Chimera RNAi
产品名称： RNASEL Pre-design Chimera RNAi
英文名称： RNASEL Pre-design Chimera RNAi
产品编号： H00006041-R03
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Homo sapiens ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (RNASEL), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_021133
- Target Region:
- Coding sequence
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 6041
- Gene Name:
- RNASEL
- Gene Alias:
- DKFZp781D08126,MGC104972,MGC133329,PRCA1,RNS4
- Gene Description:
- ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq
- Other Designations:
- 2',5'-oligoisoadenylate synthetase-dependent,OTTHUMP00000033148,interferon-induced 2-5A-dependent RNase,ribonuclease 4,ribonuclease L
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Biliary Tract Neoplasms
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Colorectal Neoplasms
- Diabetes Complications
- Disease Progression
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Hepatitis C
- Inflammation
- Lung Neoplasms
- Metabolic Syndrome X
- Neoplasms
- Obesity
- Obesity