MMP17 (Center) Peptide
产品名称： MMP17 (Center) Peptide
英文名称： MMP17 (Center) Peptide
产品编号： P1809
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MMP17.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human MMP17.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-200)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.
Jung M, Romer A, Keyszer G, Lein M, Kristiansen G, Schnorr D, Loening SA, Jung K.Prostate. 2003 May 1;55(2):89-98.
- 2.
- Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain.
Wang Y, Johnson AR, Ye QZ, Dyer RD.J Biol Chem. 1999 Nov 12;274(46):33043-9.
- 3.
- Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase.
Itoh Y, Kajita M, Kinoh H, Mori H, Okada A, Seiki M.J Biol Chem. 1999 Nov 26;274(48):34260-6.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of MMP17 polyclonal antibody (Cat # PAB4785) in NCI-H460 cell lysate (35 ug/lane). MMP17 (arrow) was detected using the purified polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with MMP17 polyclonal antibody (Cat # PAB4785) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 4326
- Protein Accession#:
- MM17_HUMAN
- Gene Name:
- MMP17
- Gene Alias:
- MT4-MMP
- Gene Description:
- matrix metallopeptidase 17 (membrane-inserted)
- Omim ID:
- 602285
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq
- Other Designations:
- matrix metalloproteinase 17,matrix metalloproteinase 17 (membrane-inserted),membrane-type matrix metalloproteinase 4,membrane-type-4 matrix metalloproteinase