FGFR2/CEN10p FISH Probe
产品名称： FGFR2/CEN10p FISH Probe
英文名称： FGFR2/CEN10p FISH Probe
产品编号： FG0018
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
- Storage Instruction:
- Store at 4°C in the dark.
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 250 uL
- Note:
Hybridization position of the probes on the chromosome.-
- Probe 1:
Size:
Fluorophore:
Location: - FGFR2
Approximately 330kb
Texas Red
10q26
- Probe 2:
Size:
Fluorophore:
Location: - CEN10p
Approximately 640kb
FITC
10p11.22
- Probe Gap:
- The gap between two probes is approximately 91,200 kb.
- Origin:
- Human
- Source:
- Genomic DNA
- Regulation Status:
- For research use only (RUO)
- Publication Reference
- 1.
- FGFR2 gene amplification and clinicopathological features in gastric cancer.
Matsumoto K, Arao T, Hamaguchi T, Shimada Y, Kato K, Oda I, Taniguchi H, Koizumi F, Yanagihara K, Sasaki H, Nishio K, Yamada Y.Br J Cancer. 2012 Jan 12. doi: 10.1038/bjc.2011.603. [Epub ahead of print]
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Human stomach carcinoma (FFPE) stained with FGFR2/CEN10p FISH Probe. Human stomach carcinoma showed FGFR2 gene amplification.
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Human breast cancer (FFPE) stained with FGFR2/CEN10p FISH Probe. Left: Human breast cancer showed no FGFR2 gene amplification. Right: Human breast cancer showed FGFR2 gene amplification (FGFR2/CEN10p ratio ≥ 2).
- Protocol Download
- Entrez GeneID:
- 2263
- Gene Name:
- FGFR2
- Gene Alias:
- BEK,BFR-1,CD332,CEK3,CFD1,ECT1,FLJ98662,JWS,K-SAM,KGFR,TK14,TK25
- Gene Description:
- fibroblast growth factor receptor 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq
- Other Designations:
- BEK fibroblast growth factor receptor,FGF receptor,OTTHUMP00000020621,OTTHUMP00000020629,bacteria-expressed kinase,hydroxyaryl-protein kinase,keratinocyte growth factor receptor,protein tyrosine kinase, receptor like 14,soluble FGFR4 variant 4
- Interactome
- Related Disease
- Acrocephalosyndactylia
- Adenocarcinoma
- Adenocarcinoma, Mucinous
- Alzheimer Disease
- Alzheimer disease
- Birth Weight
- Breast cancer
- Breast Neoplasms
- Bronchial Hyperreactivity
- Carcinoma, Basal Cell
- Carcinoma, Endometrioid
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Craniofacial Dysostosis
- Craniosynostoses
- Cystadenocarcinoma, Serous
- Depressive Disorder, Major