WRN monoclonal antibody (M09), clone 3C11
产品名称: WRN monoclonal antibody (M09), clone 3C11
英文名称: WRN monoclonal antibody (M09), clone 3C11
产品编号: H00007486-M09
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant WRN.
- Immunogen:
- WRN (NP_000544, 1322 a.a. ~ 1432 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- NPPVNSDMSKISLIRMLAPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.95 KDa) .
- MSDS:
- Download
- Applications
- Western Blot (Cell lysate)
- WRN monoclonal antibody (M09), clone 3C11 Western Blot analysis of WRN expression in Hela NE ( Cat # L013V3 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Immunofluorescence
- enlarge this image
- Immunofluorescence of monoclonal antibody to WRN on HeLa cell. [antibody concentration 10 ug/ml]
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged WRN is approximately 0.3ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 7486
- GeneBank Accession#:
- NM_000553
- Protein Accession#:
- NP_000544
- Gene Name:
- WRN
- Gene Alias:
- DKFZp686C2056,RECQ3,RECQL2,RECQL3
- Gene Description:
- Werner syndrome
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq
- Other Designations:
- Werner Syndrome helicase,Werner syndrome protein
- Related Disease
- Adenocarcinoma
- Alzheimer disease
- Arteriosclerosis
- Atherosclerosis
- Atherosclerosis
- Bone Neoplasms
- Breast cancer
- Breast Neoplasms
- Calcinosis
- Carcinoma, Ductal, Breast
- Cardiovascular Diseases
- Cataract
- Chronic Disease
- Cognition
- Cognition Disorders
- Colorectal Neoplasms
- Coronary Artery Disease
- Diabetes Mellitus, Type 2
- Edema