FITC标记的前列腺癌激活蛋白抗体
产品名称： FITC标记的前列腺癌激活蛋白抗体
英文名称： Anti-PDZK3/FITC
产品编号： HZ-9037R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-PDZK3/FITC Conjugated antibody
FITC标记的前列腺癌激活蛋白抗体
| 产品编号 | bs-9037R-FITC |
| 英文名称 | Anti-PDZK3/FITC |
| 中文名称 | FITC标记的前列腺癌激活蛋白抗体 |
| 别 名 | Activated in prostate cancer protein; AIPC; KIAA0300; Likely ortholog of rat plakophilin related armadillo repeat protein interacting PDZ protein antibody PAPIN; PDZ domain containing 2; PDZ domain containing 3; PDZ domain containing protein 2; PDZ domain containing protein 3; PDZD2; PDZK 2; PDZK2; PDZK-2; PDZK 3; PDZK3; PDZK-3; PIN1; Plakophilin related armadillo repeat protein interacting PDZ protein like; Rat plakophilin related armadillo repeat protein interacting PDZ protein like; PDZD2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 310kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PDZK3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. PDZK3 contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, the PDZK3 gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. Subunit: Interacts with SCN10A, CTNND2 and PKP4 (By similarity). Subcellular Location: Cytoplasmic, Endoplasmic reticulum, Nuclear and Secreted Tissue Specificity: Isoform 2 is expressed (at protein level) in prostate and many prostate tumors. Post-translational modifications: A secreted form is produced by caspase-mediated proteolytic cleavage (By similarity). Similarity: Contains 6 PDZ (DHR) domains. Database links: Entrez Gene: 23037 Human Entrez Gene: 68070 Mouse Entrez Gene: 65034 Rat Omim: 610697 Human SwissProt: O15018 Human SwissProt: Q9QZR8 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
含有PDZ结构域的蛋白质经常被显示为结合跨膜受体或离子通道的C-末端。它们也被证明与其他PDZ结构域蛋白结合，并且可能参与细胞内信号传导。PDZK3含有六个PDZ结构域，与前白细胞介素-16（PR-IL-16）具有序列相似性。像PR-IL-16，编码的蛋白质定位到内质网，并被认为是由胱天蛋白酶裂解产生分泌肽含有两个PDZ结构域。此外，PDZK3基因在原发性前列腺肿瘤中上调，可能参与前列腺肿瘤发生的早期阶段。