分子量：Calculated MW: 59kDa/60kDa/65kDa/67kDa/69kDa/70kDa
Observed MW: 75kDa

细胞定位：Cell membrane, Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Mitochondrion membrane, Mitochondrion outer membrane, Nucleus outer membrane, Sarcoplasmic reticulum membrane, Single-pass type IV membrane protein, cytosol

稀释方法：WB 1:500 - 1:2000

总结：The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.