FITC标记的过敏毒素C3受体/补体C3受体抗体
产品名称： FITC标记的过敏毒素C3受体/补体C3受体抗体
英文名称： Anti-C3a Receptor/FITC
产品编号： HZ-2955R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-C3a Receptor/FITC Conjugated antibody
FITC标记的过敏毒素C3受体/补体C3受体抗体
| 英文名称 | Anti-C3a Receptor/FITC |
| 中文名称 | FITC标记的过敏毒素C3受体/补体C3受体抗体 |
| 别 名 | AZ 3B; AZ3B; C3a anaphylatoxin chemotactic receptor; C3A R; C3A R1; C3a-R; C3AR; C3AR_HUMAN; C3AR1; C3R1; Complement component 3 receptor 1; Complement component 3a receptor 1; HNFAG09. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 54kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C3a Receptor/C3aR |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Complement C3 precursor contains complement C3 beta chain, complement C3 alpha chain, C3a anaphylatoxin, complement C3b alpha chain, complement C3c fragment, complement C3dg fragment, complement C3g fragment, complement C3d fragment and complement C3f fragment. C3a, C4a, and C5a are potent anaphylatoxins that are released during complement activation, a system of ligand-surface protein interactions specific to cells of hematopoietic lineage that aids in the elimination of pathogens. C3a and C5a secretion correlates with pathophysiological phenotypes such as asthma and bacterial meningitis. Binding of these proteins to their respective G protein-coupled receptors (C3aR, C5aR), which are present on the surface of myeloid leukocytes, induces proinflammatory events such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3aR is expressed in brain and activated B-lymphocytes whereas C5aR is prevalent on the surface of hepatocyte, lung, smooth muscle, and endothelial cells. Upon activation, C3aR and C5aR are susceptible to rapid GRK-mediated phosphorylation and clathrin-coated vesicle targeting. C5aR utilizes the Ras-Raf-ERK1/2 cascade and couples to Gi/G16 proteins. Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues. Post-translational modifications: Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 719 Human Entrez Gene: 12267 Mouse Entrez Gene: 84007 Rat Omim: 605246 Human SwissProt: Q16581 Human SwissProt: O09047 Mouse SwissProt: O55197 Rat Unigene: 591148 Human Unigene: 2408 Mouse Unigene: 9772 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
补体C3前体含有补体C3β链、补体C3α链、C3a过敏毒素、补体C3bα链、补体C3c片段、补体C3DG片段、补体C3G片段、补体C3d片段和补体C3F片段。C3A、C4A和C5A是在补体激活过程中释放的强有力的过敏毒素，是一种与造血谱系细胞特异的配体-表面蛋白相互作用系统，有助于消除病原体。C3a和C5a分泌与病理生理表型有关，如哮*和细菌性脑膜炎。这些蛋白与它们各自的G蛋白偶联受体（C3AR，C5AR）结合，它们存在于髓系白细胞表面，引起促炎性事件，如细胞脱颗粒、平滑肌收缩、花生四烯酸代谢、细胞因子释放、白细胞活化。细胞趋化性。C3AR在脑和活化的B淋巴细胞中表达，而C5AR在肝细胞、肺、平滑肌和内皮细胞表面普遍存在。激活后，C3AR和C5AR易受GRK介导的磷酸化和网格蛋白包被的囊泡靶向的影响。C5AR利用RAS-RAF-Erk1／2级联并耦合到GI/G16蛋白。