MAPT polyclonal antibody
产品名称： MAPT polyclonal antibody
英文名称： MAPT polyclonal antibody
产品编号： PAB3865
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MAPT.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MAPT.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes.
Yoshiyama Y, Zhang B, Bruce J, Trojanowski JQ, Lee VM.J Neurosci. 2003 Nov 19;23(33):10662-71.
- 2.
- Nitration of tau protein is linked to neurodegeneration in tauopathies.
Horiguchi T, Uryu K, Giasson BI, Ischiropoulos H, LightFoot R, Bellmann C, Richter-Landsberg C, Lee VM, Trojanowski JQ.Am J Pathol. 2003 Sep;163(3):1021-31.
- 3.
- Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease.
Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, Miller R, Berry RW, Binder LI, Cryns VL.Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10032-7. Epub 2003 Jul 29.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of MAPT (arrow) using MAPT polyclonal antibody (Cat # PAB3865).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAPT gene (Lane 2).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with MAPT polyclonal antibody (Cat # PAB3865) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
- Entrez GeneID:
- 4137
- Protein Accession#:
- NP_058519;P10636
- Gene Name:
- MAPT
- Gene Alias:
- DDPAC,FLJ31424,FTDP-17,MAPTL,MGC138549,MSTD,MTBT1,MTBT2,PPND,TAU
- Gene Description:
- microtubule-associated protein tau
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq
- Other Designations:
- G protein beta1/gamma2 subunit-interacting factor 1,microtubule-associated protein tau, isoform 4
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Amyloidosis
- Amyotrophic Lateral Sclerosis
- Amyotrophic lateral sclerosis
- Aphasia, Primary Progressive
- Atherosclerosis
- Atherosclerosis
- Atrophy
- Autistic Disorder
- Brain Concussion
- Brain Diseases
- Brain Ischemia
- Cardiovascular Diseases
- Carotid Stenosis
- Cleft Lip
- Cleft Palate
- Cognition
- Cognition Disorders