Anti-FAS Polyclonal Antibody

品牌：solarbio | 货号：K000322P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K000322P-50ul	solarbio	50ul	960.00元
K000322P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-FAS Polyclonal Antibody
别名	ALPS1A;APO-1;APT1;CD95;FAS1;FASTM;TNFRSF6
应用	WB IHC
稀释比例	WB 1:500-2000. IHC 1:50-100.
蛋白分子量	38kDa
Gene ID	355
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	A synthetic peptide of human FAS
性状	液体
Public Immunogen Range	A synthetic peptide of human FAS
Subcellular Locations	Cell membrane Secreted Single-pass type I membrane protein
Swiss Prot	P25445
克隆类型	Polyclonal Antibody
背景资料	The protein encoded by this gene is a member of the TNF- receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.