Uniprot ID:Q13490
Species Reactivity:Human
Antibody type:Polyclonal Antibody
Aliases:C-IAP1,IAP homolog B,Inhibitor of apoptosis protein 2,IAP-2,hIAP-2,hIAP2,RING finger protein 48,TNFR2-TRAF-signaling complex protein 2,BIRC2,API1, IAP2, MIHB, RNF48Raised in:Rabbit
Background\Function :Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
Stroage Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purity:Antigen Affinity Purified
武汉华美生物工程有限公司专营基因、蛋白、抗体、ELISA试剂盒、诊断试剂原料、药物残留、食品安全小分子及其他小分子等高质量生物产品，我们的产品涉及血管生成、细胞凋亡/自噬、合成/代谢、血液凝固、细胞粘附、细胞周期、补体、发育蛋白、DNA损伤/DNA修复、细胞因子、药物残留与食品安全、受精作用、生长因子、神经生物学、氧化应激、信息受体、转录/转录调控、运输、泛素、信号传导通路、自身免疫等多个研究领域，包括涵盖37个种属的多达万种的ELISA试剂盒。详细信息请登录：www.cusabio.cn/